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KMID : 1137020080190020123
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Journal of Gynecologic Oncology
2008 Volume.19 No. 2 p.123 ~ p.128
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Original Article : Experiences of pretreatment Laparoscopic surgical staging in patients with Locally advanced cervical cancer: results of a prospective study
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Lim Myong-Cheol
Bea Jaeman
Park Jeong-Yeol
Yim Soyi
Kang Sok-Bom
Seo Sang-Soo
Kim Joo-Yong
Kim Joo-Yong
Rho Ju-Won
Park Sang-Yoon
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Abstract
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Objectives: To prospectively evaluate the feasibility, safety, and survival of laparoscopic surgical staging in patients with locally advanced cervical cancer.
Methods: From Oct 2001 to Jul 2006, a total of 83 consecutive patients were eligible for inclusion and underwent
laparoscopic surgical staging.
Results: Three patients with intraoperative great vessel injury and 1 patient in whom the colpotomizer was unable to be inserted were excluded. Laparoscopic surgical staging was feasible in 95.2% (79/83). Immediate postoperative
complications were noted in 12 (15.2%) patients. Prolonged complications directly related to operative procedures
numbered 2 (2.5%), and were trocar site metastases. The mean time from surgery to the start of radiotherapy (RT) or
concurrent chemoradiotherapy (CCRT) was 11 (5-35) days. All patients tolerated the treatment well and completed scheduled RT or CCRT without disruption of treatment and additional admission. The rate of modification of the
radiation field after surgical staging was 8.9% (7/79). Five-year progression-free survival and overall survival (OS)
rates were 79% and 89%, respectively. The OS of patients with microscopic lymph node metastases, which were fully
resected, were comparable to those of patients without lymph node metastasis. However, the OS of patients with
macroscopic lymph node metastases that were fully resected were poorer compared with those of patients without
lymph node metastasis.
Conclusion: Pretreatment laparoscopic surgical staging is a feasible and safe treatment modality. However the survival benefit of debulking lymph nodes or full lymph node dissection is not clear.
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KEYWORD
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Cervical cancer, Laparoscopic surgical staging, Lymph nodes
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